Whole-Genome Sequencing of Pasteurella multocida Strain Pm1, Isolated from a Calf. Gondaira S, Fujiki J, Hirano Y, Murata R, Uchida I, Usui M, Iwasaki T, Okabayashi T, Iwano H, Higuchi H. Microbiol Resour Announc. 11(4):e0004222. 2022.
Relationship between Escherichia coli virulence factors, notably kpsMTII, and symptoms of clinical metritis and endometritis in dairy cows. Yamamura F, Sugiura T, Munby M, Shiokura Y, Murata R, Nakamura T, Fujiki J, Iwano H. J Vet Med Sci. 84(3):420-428. 2022.
Bisphenol A-sulfate conjugate disrupts AURKA transcription and cell cycle in BeWo cytotrophoblasts. Fujiki J, Uchida M, Tsunoda S, Maeda N, Inoue H, Yokota H, Iwano H. Mol Cell Endocrinol. 545: 111561. 2022. *: corresponding author.
Testicular induced corticosterone synthesis in male rats under fasting stress. Maeda N, Fujiki J, Hasegawa Y, Ieko T, Miyasho T, Iwasaki T, Yokota H. Steroids. 177: 108947. 2022.
Fluctuating Bactriophage-induced galU Deficiency Region is Involved in Trade-off Effects on the Phage and Fluoroquinolone Sensitivity in Pseudomonas aeruginosa. Nakamura K, Fujiki J, Nakamura T, Furusawa T, Gondaira S, Usui M, Higuchi H, Tamura Y, Iwano H. Virus Res. 306: 198596. 2021.
Novel Virulent Bacteriophage ΦSG005, Which Infects Steptococcus gordonii, Forms a Distinct Clade among Streptococcus Viruses. Fujiki J, Yoshida S, Nakamura T, Nakamura K, Amano Y, Nishida K, Nishi K, Sasaki M, Iwasaki T, Iwasaki T, Sawa H, Komatsuzawa H, Hijioka H, Iwano H. Viruses. 13(10). 1964. 2021.
Complete Genome Sequence of Pseudomonas aeruginosa veterinary isolate, Pa12. Microbiol Resour Announc. Nakamura K, Fujiki J, Furusawa T, Nakamura T, Gondaira S, Sasaki M, Usui M, Higuchi H, Sawa H, Tamura Y, Iwano H. 10(26). 2021.
Innate immune response in bovine neutrophils stimulated with Mycoplasma bovis. Gondaira S, Nishi K, Fujiki J, Iwano H, Watanabe R, Eguchi A, Hirano Y, Higuchi H, Nagahata H. Vet Res. 16;52(1): 58. 2021
Invasion of Mycoplasma bovis into synovial cells utilizing clathrin-dependent endocytosis pathway. Nishi K, Gondaira S, Fujiki J, Katagata M, Sawada C, Eguchi A, Iwasaki T, Iwano H, Higuchi H. Vet Microbiol. 253: 108956. 2021.
Transcriptome analysis of Mycoplasma bovis stimulated bovine peripheral blood mononuclear cells. Gondaira S, Nishi K, Iwano H, Fujiki J, Watanabe R, Eguchi A, Hirano Y, Higuchi H, Nagahata H. Vet Immunol Immunopathol. 232: 110166. 2021.
Susceptibility of Pseudomonas aeruginosa veterinary isolates to Pbunavirus PB1-like phages. Fujiki J, Furusawa T, Munby M, Kawaguchi C, Matsuda Y, Shiokura Y, Nakamura K, Nakamura T, Sasaki M, Usui M, Iwasaki T, Gondaira S, Higuchi H, Sawa H, Tamura Y, Iwano H. Microbiol Immunol. 2020 Nov;64(11):778-782. doi: 10.1111/1348-0421.12846. Epub 2020 Oct 19.PMID: 32918505
Lytic Activity of Polyvalent Staphylococcal Bacteriophage PhiSA012 and Its Endolysin Lys-PhiSA012 Against Antibiotic-Resistant Staphylococcal Clinical Isolates From Canine Skin Infection Sites. Nakamura T, Kitana J, Fujiki J, Takase M, Iyori K, Simoike K, Iwano H.Front Med (Lausanne). 2020 Jun 10;7:234. doi: 10.3389/fmed.2020.00234. eCollection 2020.PMID: 32587860
Local biosynthesis of corticosterone in rat skeletal muscle. Sato M, Sugiyama K, Maeda N, Fujiki J, Ieko T, Kawamura Y, Iwano H, Mukai K, Yokota H. J.Steroid Biochem. Mol. Biol. 2020 Jul;201:105693. doi: 10.1016/j.jsbmb.2020.105693. Epub 2020 May 11.PMID: 32437963
Mycoplasma bovis induces matrix metalloproteinase-3 expression in bovine synovial cells via up-regulation of interleukin-1β expression in mononuclear cells. Nishi K, Gondaira S, Okamoto M, Watanabe R, Hirano Y, Fujiki J, Iwano H, Higuchi H.Vet Immunol Immunopathol. 2020Sep;227:110057. doi:10.1016/j.vetimm.2020.110057.Epub 2020 May 31.PMID: 32554268
Transcriptome analysis of Mycoplasma bovis stimulated bovine peripheral blood mononuclear cells. Gondaira S, Nishi K, Iwano H, Fujiki J, Watanabe R, Eguchi A, Hirano Y, Higuchi H, Nagahata H. Vet Immunol Immunopathol. 2020 Dec 5;232:110166. doi: 10.1016/j.vetimm.2020.110166. Online ahead of print.PMID: 33348232
Whole-Genome Sequence of Fluoroquinolone-Resistant Escherichia coli HUE1, Isolated in Hokkaido, Japan. Munby M, Fujiki J, Aoki K, Kawaguchi C, Nakamura K, Nakamura T, Sasaki M, Sato T, Usui M, Sawa H, Yokota SI, Tamura Y, Iwano H. Microbiol Resour Announc. 2020 Nov 12;9(46):e01135-20. doi:10.1128/MRA.01135-20.PMID: 33184163
Glucuronidation as a metabolic barrier against zearalenone in rat everted intestine Ieko T, Inoue S, Inomata Y, Inoue H, Fujiki J, Iwano H. J Vet Med Sci. 12月 2019. doi: 10.1292/jvms.19-0570.
Effect of Mycoplasma bovis on expression of inflammatory cytokines and matrix metalloproteinases mRNA in bovine synovial cells.Nishi K, Gondaira S, Okamoto M, Nebu T, Koiwa M, Ohtsuka H, Murai K, Matsuda K, Fujiki J, Iwano H, Nagahata H, Higuchi H Veterinary immunology and immunopathology 216 109920 2019年10月
Immunosuppression in cows following intramammary infusion of Mycoplasma bovis. Gondaira S, Nishi K, Tanaka T, Yamamoto T, Nebu T, Watanabe R, Konnai S, Hayashi T, Kiku Y, Okamoto M, Matsuda K, Koiwa M, Iwano H, Nagahata H, Higuchi H. Infect Immun. 2019 12月. doi: 10.1128/IAI.00521-19
Analysis of Corticosterone and Testosterone Synthesis in Rat Salivary Gland Homogenates. Ieko T, Sasaki H, Maeda N, Fujiki J, Iwano H, Yokota H.Front Endocrinol (Lausanne). 2019 10:479
Corticosterone biosynthesis in mouse clonal myoblastic C2C12 cells. Fujiki J, Maeda N, Sato M, Ieko T, Inoue H, Iwasaki T, Iwano H, Yokota H. Steroids. 2018 Oct;138:64-71.
Biotransformation of Bisphenol A and Its Adverse Effects on the Next Generation. Iwano H, Inoue H, Nishikawa M, Fujiki J and Yokota H. IntechOpen Book title: Endocrine Disruptors. 2018 Chapter 5 63-78. http://dx.doi.org/10.5772/intechopen.78275
Identification of a novel mechanism of action of bovine IgG antibodies specific for Staphylococcus aureus. Furukawa M, Yoneyama H, Hata E, Iwano H, Higuchi H, Ando T, Sato M, Hayashi T, Kiku Y, Nagasawa Y, Niimi K, Usami K, Ito K, Watanabe K, Nochi T, Aso H. Vet Res. 2018 Feb 26;49(1):22. doi: 10.1186/s13567-018-0517-y.
Characterization of the Lytic Capability of a LysK-Like Endolysin, Lys-phiSA012, Derived from a Polyvalent Staphylococcus aureus Bacteriophage. Fujiki J, Nakamura T, Furusawa T, Ohno H, Takahashi H, Kitana J, Usui M, Higuchi H, Tanji Y, Tamura Y, Iwano H. Pharmaceuticals (Basel). 2018 Feb 24;11(1). pii: E25. doi: 10.3390/ph11010025.
Late pregnancy is vulnerable period for exposure to BPA. Ohtani N, Suda K, Tsuji E, Tanemura K, Yokota H, Inoue H, Iwano H. J Vet Med Sci. 2018 Mar 30;80(3):536-543. doi: 10.1292/jvms.17-0460. Epub 2018 Jan 25.
Bacteriophage ΦSA012 Has a Broad Host Range against Staphylococcus aureus and Effective Lytic Capacity in a Mouse Mastitis Model. Iwano H, Inoue Y, Takasago T, Kobayashi H, Furusawa T, Taniguchi K, Fujiki J, Yokota H, Usui M, Tanji Y, Hagiwara K, Higuchi H, Tamura Y. Biology (Basel). 2018 Jan 9;7(1). pii: E8. doi: 10.3390/biology7010008.
Adverse effects of maternal exposure to bisphenol F on the anxiety- and depression-like behavior of offspring. Ohtani N, Iwano H, Suda K, Tsuji E, Tanemura K, Inoue H and Yokota H. J Vet Med Sci. 2017;79(2):432-439.
Blood biochemistry and hematological changes in rats after administration of a mixture of three anesthetic agents. Ochiai Y, Baba A, Hiramatsu M, Toyota N, Watanabe T, Yamashita K, Yokota H, Iwano H. J Vet Med Sci. 2017 Dec 18. doi: 10.1292/jvms.17-0497.
Phage therapy is effective in a mouse model of bacterial equine keratitis. Furusawa T, Iwano H, Hiyashimizu Y, Matsubara K, Higuchi H, Nagahata H, Niwa H, Katayama Y, Kinoshita Y, Hagiwara K, Iwasaki T, Tanji Y, Yokota H and Tamura Y. Applied and Environmental Microbiology. 82(17):5332-9. (2016).
Complete Genome Sequencing of the Broad-Host-Range Pseudomonas aeruginosa Bacteriophages ΦR18 and ΦS12-1. Furusawa T, Iwano H, Higuchi H, Usui M, Maruyama F, Nakagawa I, Yokota H and Tamura Y. Genome Announcements. 4(3) pii: e00041-16. (2016).
Blood biochemical changes in mice after administration of a mixture of three anesthetic agents. Ochiai Y, Iwano H, Sakamoto T., Hirabayashi M, Kaneko E, Watanabe T, Yamashita K and Yokota H. J. Vet. Med. Sci. 78(6):951-6 (2016).
Bisphenol A Glucuronide/Sulfate Diconjugate in Perfused Liver of Rats. Inoue H, Kemanai S, Sano C, Kato S, Yokota H. and Iwano H. J. Vet. Med. Sci. 78(5):733-7. (2016).
Bacteriophage can lyse antibiotic-resistant Pseudomonas aeruginosa isolated from canine diseases. Furusawa T, Iwano H, Higuchi H, Yokota H, Usui M and Tamura Y. J. Vet. Med. Sci. 78(6):1035-8 (2016).
Suppression of liver Apo E secretion leads to HDL/cholesterol immaturity in rats administered ethinylestradiol. Yamaguchi K, Ishii M, Maeda N, Iwano H, Yokota H. FEBS Open Bio. 2016 Jul 21;6(9):928-36. doi: 10.1002/2211-5463.12098.
Therapeutic potential of endothelin inhibitors in canine hemangiosarcoma. Fukumoto S, Saida K, Sakai H, Ueno H, Iwano H, Uchide T. Life Sci. 159:55-60. (2016).
Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development. Yabusaki, R., Iwano, H., Tsuahima, S., Koike, N., Tanemura, K., Inoue, H., Yokota, H., J Vet Med Sci. 77: 1479-1484. (2015)
Significance of caveolin-1 and matrix metalloproteinase 14 gene expression in canine mammary tumours. Ebisawa, M., Iwano, H., Nishikawa, M., Tochigi, Y., Komatsu, T., Endou, Y., Hirayama, K., Taniyama, H., Kadosawa, T., Yokota, H. Vet J. 206:191-196. (2015)
Cytokine mRNA profiling and the proliferative response of bovine peripheral blood mononuclear cells to Mycoplasma bovis. Gondaira, S., Higuchi, H., Iwano, H., Nakajima, K., Kawai, K., Hashiguchi, S., Konnai, S., and Nagahata, H. Vet Immunol Immunopathol. May 15;165(1-2):45-53. (2015)
Epidermal Growth Factor Receptor Expression in Canine Transitional Cell Carcinoma. Hanazono, K., Fukumoto, S., Kawamura, Y., Endo, Y., Kadosawa, T., Iwano, H. and Uchide, T. J Vet Med Sci. 77:1-6. (2015)
Antimicrobial susceptibilities of Mycoplasma isolated from bovine mastitis in Japan. Kawai, K., Higuchi, H., Iwano, H., Iwakuma, A., Onda, K., Sato, R., Hayashi, T., Nagahata, H, and Oshida, T. Anim Sci J. 85: 96-99. (2014)
Serum big endothelin-1 as a clinical marker for cardiopulmonary and neoplastic diseases in dogs. Fukumoto, S., Hanazono, K., Miyasho, T., Endo, Y., Kadosawa, T., Iwano, H, and Uchide, T. Life Sci. 118:329-332. (2014)
Temporal Changes in Environmental Health Risks andSocio-Psychological Status in Areas Affected by the 2011 Tsunami in Ishinomaki, Japan. Makita, M., Inoshita, K., Kayano, T., Uenoyama, K., Hagiwara, K., Asakawa, M., Ogawa, K., Kawamura, S., Noda, J., Sera, K., Sasaki, H., Nakatani, N., Higuchi, H., Ishikawa, N., Iwano, H. and Tamura, Y. Environment and Pollution; Vol. 3, No. 1. (2014)
Effect of dietary eugenol on xenobiotic metabolism and mediation of UDP-glucuronosyltransferase and cytochrome P450 1A1 expression in rat liver. Iwano, H., Ujita, W., Nishikawa, M., Ishii, S., Inoue, H., Yokota, H. Int J Food Sci Nutr. 65:241-214. (2014)
Effects of vitamin E supplementation on cellular α-tocopherol concentrations of neutrophils in Holstein calves. Higuchi, H., Ito, E., Iwano, H., Oikawa, S. and Nagahata, H. Can J Vet Res. 77:120-5. (2013)
Relationship between concentration of lingual antimicrobial peptide and somatic cell count in milk of dairy cows. Kawai, K., Akamatsu, H., Obayashi, T., Nagahata, H., Higuchi, H., Iwano, H., Oshida, T., Yoshimura, Y. and Isobe, N. Vet Immunol Immunopathol. 15;153(3-4):298-301. (2013)
Mycoplasma species isolated from intramammary infection of Japanese dairy cows. Higuchi, H., Gondaira, S., Iwano, H., Hirose, K., Nakajima, K., Kawai, K., Hagiwara, K., Tamura, Y, and Nagahata, H. Vet Rec. 172(21):557. (2013)
L-type amino acid transporter 1 (LAT1) expression in canine mammary gland tumors. Fukumoto, S., Hanazono, K., Komatsu, T., Iwano, H., Kadosawa, T. and Uchide, T. J. Vet. Med. Sci. 75:431-437. (2013)
L-type amino acid transporter 1 (LAT1): a new therapeutic target for canine mammary gland tumour. Fukumoto, S., Hanazono, K., Komatsu, T., Ueno, H., Kadosawa, T. Iwano, H. and Uchide, T. Vet. J. 198: 164-169. (2013)
A new treatment for human malignant melanoma targeting L-type amino acid transporter 1 (LAT1): a pilot study in a canine model. Fukumoto, S., Hanazono, K., Dah-Renn, FU., Endo, Y., Kadosawa, T., Iwano, H. and Uchide, T. Biochem. Biophys. Res. Commun. 439: 103-108. (2013)
Analysis of trace and major elements in bronchoalveolar lavage fluid of Mycoplasma bronchopneumonia in calves. Suzuki, K., Higuchi, H., Iwano, H., Lakritz, J., Sera, K., Koiwa, M. and Taguchi, K.. Biol. Trace. Elem. Res. 145(2):166-71. (2012)
Pathological classification of canine mammary tumor based on quantifying mRNA levels of hormonal receptors, SATB1, and snail in tissue and fine needle biopsy samples. Komatsu, T., Iwano, H., Ebisawa, M., Watabe, A., Endo, Y., Hirayama, K., Taniyama, H, and Kadosawa, T. J. Vet. Med. Sci. 74(6):719-26. (2012)
A simplified PCR assay for fast and easy mycoplasma mastitis screening in dairy cattle. Higuchi, H., Iwano, H., Kawai, K., Ohta, T., Obayashi, T., Hirose, K., Itoh, N., Yokota, T., Tamura, Y. and Nagahata, H. J. Vet. Sci., 12: 191-193. (2011)
Prevalence of Mycoplasma species in bulk tank milk in Japan. Higuchi, H., Iwano, H., Gondaira, S., Kawai, K. and Nagahata, H. Vet. Rec., 169:442. (2011)
Placental Transfer of Conjugated Bisphenol A and Subsequent Reactivation in the Rat fetus. Nishikawa, M., Iwano, H., Yanagisawa, R., Koike, N., Inoue H. and Yokota H. Environ. Health Perspect. 118: 1196-1203. (2010)
Histone H1 null vertebrate cells exhibit altered nucleosome architecture. Hashimoto, H., Takami, Y., Sonoda, E., Iwasaki, T., Iwano, H., Tachibana, M., Takeda, S., Nakayama, T., Kimura, H. and Shinkai, Y. Nucleic Acids Res. 2010;383533-38345. (2010)
Isolation from sewage influent and characterization of novel Staphylococcus aureus bacteriophages with wide host range and potent lytic capability. Synnott, A. J., Kuang, Y., Kurimoto, M., Yamamichi, K., Iwano, H. and Tanji, Y. Appl. Env. Microbiol., 75, 4283-4490. (2009)
Expression of monocarboxylate transporter 1 in oral and ocular canine melanocytic tumors. Shimoyama, Y., Akihara, Y., Kirat, D., Iwano, H., Hirayama, K., Kagawa,Y., Ohmachi, T., Mstsuda, K., Okamoto, M., Kadosawa, T., Yokota, H. and Taniyama, H. Vet. Pathol. 44(4):449-457. (2007)
Metabolic barrier against bisphenol A in rat uterine endometrium. Matsumoto, J., Iwano, H., Inoue, H., Iwano, N., Yamashiki, N. and Yokota, H. Toxicol. Sci. 99(1):118-25. (2007)
Expression of monocarboxylate transporter 1 (MCT1) in the dog intestine. Shimoyama, Y., Kirat, D., Akihara, Y., Kawasako, K., Komine, M., Hirayama, K., Matsuda, K., Okamoto, M., Iwano, H., Kato, S. and Taniyama, H. J Vet Med Sci.;69(6):599-604. (2007)
Monocarboxylate transporter 1 (MCT1) in the liver of pre-ruminant and adult bovines. Kirat, D., Inoue, H., Iwano, H., Yokota, H., Taniyama, H. and Kato, S. Vet. J. 173:124-130. (2007)
Monocarboxylate transporter 1 gene expression in the ovine gastrointestinal tract. Kirat, D., Inoue, H., Iwano, H., Hirayama, K., Yokota, H., Taniyama, H. and Kato, S. Vet J. 171:462-467. (2006)
Down regulation of bisphenol A glucuronidation in carp during the winter pre-breeding season.Daidoji, T., Kaino T., Iwano, H., Inoue, H., Kurihara R., Hashimoto, S. and Yokota, H. Aquat. Toxicol. 77: 386-392. (2006)
Expression and distribution of monocarboxylate transporter 1 (MCT1) in the gastrointestinal tract of calves. Kirat, D., Inoue, H., Iwano, H., Hirayama, K., Yokota, H., Taniyama, H. and Kato, S. Res Vet Sci. 79:45-50. (2005)
UDP-glucuronosyltransferase isoforms catalyzing glucuronidation of hydroxy-polychlorinated biphenyls in rat. Daidoji, T., Gozu, K., Iwano, H., Inoue, H. and Yokota, H. Drug. Metab. Dispos. 33: 1466-1476. (2005)
Xenopus MBD3 plays a crucial role in early stage of development. Iwano, H., Nakamura, M. and Tajima, S. Dev., Biol. 268: 416-428. (2004)
cDNA cloning and expression of a bovine phenol UDP-glucuronosyltransferase, BovUGT1A6. Iwano, H., Yotsumoto, N., Yokota, H. and Yuasa, A. Life Sci. 68: 2131-2139. (2001)
Smooth muscle layer-dependent distribution of 5-hydroxytryptamine(7) receptor in the porcine myometrium. Kitazawa, T., Yamada, Y., Iwano, H., Yokota, H., Yuasa, A, and Taneike, T. Br. J. Pharmacol. 130: 79-89. (2000)
Glucuronidation of the environmental oestrogen bisphenol A by an isoform of UDP-glucuronosyltransferase, UGT2B1, in the rat liver. Yokota, H., Iwano, H., Endo, M., Kobayashi, T., Inoue, H., Ikushiro, S. and Yuasa, A. Biochem J. 340: 405-409. (1999)
The significance of amino acid residue Asp446 for enzymatic stability of rat UDP-glucuronosyltransferase UGT1A6. Iwano, H., Yokota, H., Ohgiya, S. and Yuasa, A. Arch Biochem Biophys. 363: 116-120. (1999)
UDP-glucuronosyltransferase UGT1A7 induced in rat small intestinal mucosa by oral administration of 2-naphthoflavone. Kobayashi, T., Yokota, H., Ohgiya, S., Iwano, H. and Yuasa, A. Eur J Biochem. 258: 948-955. (1998)
Inhibitory effects of uridine diphosphate on UDP-glucuronosyltransferase. Yokota, H., Ando, F., Iwano, H. and Yuasa, A. Life Sci. 63: 1693-1699. (1998)
A critical amino acid residue, asp446, in UDP-glucuronosyltransferase. Iwano, H., Yokota, H., Ohgiya, S., Yotumoto, N. and Yuasa A. Biochem J. 325: 587-591. (1997)
High induction of phenol UDP-glucuronosyltransferase in the kidney medulla of beta-naphthoflavone-treated rats. Yokota, H., Inoue, H., Taniyama, H., Kobayashi, T., Iwano, H., Kagawa, Y., Okada, H and Yuasa, A. Biochim Biophys Acta. 1336: 165-170. (1997)
